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Because the under-eye area is so delicate, thinning skin allows underlying blood vessels to show through and cast a dark, purplish shadow

If you also have a fever, chills or unexplained weight loss, its time to call your doctor. 5

Furthermore, LPS may induce vascular inflammation, increase the expression of adhesion molecules, and facilitate the migration of inflammatory cells to the site [184]

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Similarly, ROS promote autophagy as a stress response, which can be prevented by glutamine, through the production of glutathione and NADPH